Folic Acid

Folic Acid Uses

Except the benefits for pregnant women, folic acid also ensures the improvements for some medical conditions:

  • Depression: People who lack folic acid in their body are much more susceptible to depression. But the supplementation with folic acid enhances the effects of other remedies aimed at fighting depression. This will bring a long-awaited psychological relief to the depression sufferers.
  • Heart Disease: Different heart diseases develop due to the increased activity of homocysteine known as an inflammatory molecule. The negative effects of this molecule are especially severe in case of overweigh and obesity. Folic acid makes the levels of homocysteine drop. There is some clinical proof that this effect serves for the prevention of heart disease, especially in the combination with the use of the natural fat burners for women.
  • Autism: According to the study evidence, autism prevention is possible due to the use of folic acid by the women during pregnancy. This helps reduce the probability of giving a birth to a baby with autism. However, more clinical trials are required to understand the mechanism of folic acid action in this case.
  • Rheumatoid Arthritis: Folic acid increases the efficacy of the prescription rheumatoid arthritis therapy with the use of methotrexate medication. Thus, the intake of folic acid helps decrease digestive side effects of this drug by 79%.

Side Effects and Precautions

People who are going to take folic acid should get acquainted with a range of side effects and precautions before starting the supplementation. The possible side effects which typically emerge due to the folic acid misuse are as follows:

  • Trouble sleeping
  • Bitter taste in the mouth
  • Substantial appetite reduction
  • Nausea
  • Flushing
  • Bloating
  • Excitement and irritability
  • Depression

You shouldn’t use folic acid if you can’t tolerate it. Otherwise, you will deal with the allergic reactions such as trouble breathing, swelling in the mouth and throat, and hives.

Also, it’s advisable to be very careful with the intension to take folic acid if you suffer from the following medical conditions:

  • Kidney disease
  • Dialysis
  • Undiagnosed anemia
  • Pernicious anemia
  • Hemolytic anemia
  • Infectious diseases
  • Alcoholic abuse

In case of the mentioned medical conditions, you should discuss with your doctor a possibility and reasonability of the folic acid intake.

Folic Acid Interactions

When you are going to take folic acid for any reason, you should be aware of the following possible interactions:

  • Cerebyx (Fosphenytoin): This medication is taken for the prevention and management of seizures. When folic acid is combined with Fosphenytoin, the latter one becomes less effective for controlling seizures.
  • Methotrexate: This drug is used for treating rheumatoid arthritis, severe psoriasis, some types of cancer and autoimmune diseases. But its efficacy lowers under the influence of folic acid. At the same time, the medication also decreases the efficacy of folic acid itself.
  • Phenobarbital: It is a sedative medication that belongs to barbiturates used to overcome anxiety, tension, depression, insomnia, and seizures. The combination of phenobarbital with folic acid makes phenobarbital less helpful.
  • Phenytoin: This is an antiepileptic drug aimed at preventing seizures. The intake of Phenytoin along with folic acid suppresses the effects of this medication.
  • Primidone: This medication is in the list of famous anticonvulsants. It is prescribed for controlling seizures. But if the patient also administers folic acid, Primidone will stop working well.
  • Pyrimethamine: It’s a remedy applied for curing parasitic diseases. This medication may be inhibited if the patient uses folic acid simultaneously with it.

As for endocrinology, folic acid can be even taken in order to support the treatment of some endocrine diseases. Thus, there is scientific evidence that the elevation of folic acid contributes to the reduction of homocysteine levels in the patients with hypothyroidism. So, folic acid may be potentially beneficial for easing the disease symptoms in such patients if the doctor deems it appropriate.

Folic Acid Dosage

The majority of folic acid supplements freely available as non-prescription remedies are represented as 400 mcg tablets.

Prescription folic acid is the form of folic acid typically taken by pregnant women. There is 1 mg (1,000 mcg) of folic acid in such tablets.

Healthy adult people who are more than 18 years old as well as pregnant women are discouraged from taking the dosage that exceeds 1,000 mcg of folic acid per day.

As for children, the dosage of folic acid them varies depending on the age. The dosage of folic acid shouldn’t exceed 600 mcg for children from 9 to 13 years old and 800 mcg for children from 14 to 18 years old.

It’s strongly not recommended to self-determine the dosage of folic acid. Only the healthcare provider can decide how much folic acid you can take per day based on the results of physical exam, your medical history, and existing medical conditions. The use of folic acid usually doesn’t impede the effects of over-the-counter appetite suppressants though the doctor’s consultation is needed.

If there is a suspicion that you are experiencing overdosing with the symptoms such as tiredness, troubled concentration, weakness, confusion, tingling, and numbness, you have to urgently visit a doctor.

How Folic Acid and Folate Differ

The users frequently confuse and alternate folic acid and folate because both of these substances belong to the vitamin B9 forms. However, they are not the same since each of these forms has own significant peculiarities. Folate occurs naturally and is available in whole foods like citrus fruits, eggs, and vegetables. Folic acid is the artificial form of vitamin B9 added to processed foods and different supplements which can be by the way taken along with TestoGen.

The matter is that approximately 60% of women have an abnormal MTHFR gene which prevents the normal transformation of artificial folic acid into bioavailable methylfolate. Due to this, the bodies of women who consume folic acid are just unable to absorb B vitamins properly and get all benefits related to the use of these vitamins. That’s why it’s strongly recommended to replace the artificial folic acid by means of using folate derived from whole foods or taking the naturally-emerged active folate in the form of supplement, even if the woman also takes Forskolin 250.

So the natural bioavailable folate is the best option. However, if you still wish to take the supplementation with a synthetic folic acid, you should consult your healthcare provider to choose the healthiest and most effective remedy.

Folic Acid Fortification

Fortification is a method applied to enrich foods with some very crucial mineral and vitamins which form a backbone of public health and are irreplaceable for the majority of population. Since folic acid is an extremely essential vitamin, the Food and Drug Administration decided that it’s necessary to start adding folic acid to foods in 1998. The US statistics tells that about 50% of all pregnancies in the US are not planned. That’s why these women don’t ensure the prevention of birth defects before pregnancy and their babies may have health problems after birth. The infant health risks can be effectively decreased folic acid fortification.

The range of foods chosen for fortification includes gain products like pasta, rice, cereal, and bread. When the women of childbearing age regularly get some small but still sufficient dosage of folic acid, her body will be ready to carry a healthy child without neural tube defects in case of sudden pregnancy.

Anyway, if the woman plans pregnancy, she should consult the doctors concerning the additional daily consumption of folic acid because the amount of fortified foods she eats may not include an adequate dosage of this vitamin.

Folate Deficiency

Folate deficiency may develop if a person doesn’t consume a sufficient amount of folate and folate levels in the body drop belong the normal range. When the person is folate-deficient, megaloblastic anemia may afflict the body. If folate deficiency happens during pregnancy, the probability of occurrence of congenital abnormalities upsurges.

There are the following symptoms which may accompany folate deficiency:

  • Tiredness
  • Headache
  • Concentration impairment
  • Rapid heart rate
  • Irritability
  • Weakness
  • Mouth and tongue ache
  • Changes in fingernail, hair, or skin color
  • Difficulty breathing

There are the following groups of people who are much more prone to folate deficiency:

  • Alcohol abusers
  • Pregnant women
  • Women of childbearing age
  • People suffering from nutrient absorption diseases such as celiac disease and irritable bowel syndrome
  • Patients suffering from MTHFR polymorphism which is in fact the abnormal variation of MTHFR gen that elevates the probability of neutral tube defects

Folate deficiency can be successfully reversed with the help of proper folate supplementation.

What Is Folate Deficiency?

Folate, also known as vitamin B9, is classified as B group vitamin that participates in cell metabolism. Normal secretion of proteins, RNA, and DNA doesn’t occur without folate. If the body lacks this vitamin and the body becomes folate-deprived, cells can’t divide in a healthy way and harmful toxins are not removed from cells. This vitamin also synergistically acts with vitamin B12 by managing the production of red blood cells in the body. And the intake of most advanced OTC HGH supplements doesn’t impair folate levels in the body.

Even folic acid which you take as a supplement then undergoes the transformation into folate in the body. Some animal food and green leafy vegetables belong to the natural sources of folate. But there are the cases when both ordinary folic acid supplementation and intake of folate-containing food can’t meet the body’s needs for folate. Malnutrition only aggravates the situation. When the body doesn’t get enough folate for a long time, folate deficiency develops, especially when the body’s demand for this vitamin grows.

Folate deficiency most frequently occurs in women who are pregnant and breastfeeding. People struggling against chronic diseases of digestive system also may suffer from folate deficiency. The followers of extreme diets are also tending to be folate-deficient. But note that the use of natural diet pills doesn’t contribute to the problems with the levels of folate in the body. In addition, the persons who suffer from medication and alcohol abuse as well as the elderly adults over 65 years old are also prone to folate deprivation.

Vitamin B9 deficiency doesn’t disappear by itself. It should be resolved with the help of special treatment.

Symptoms of Folate Deficiency

The most frequently occurring symptoms of folate deficiency are as follows:

  • Constant exhaustion, sluggishness, and lethargy
  • Decreased muscle strength
  • Neurological symptoms like tingling, prickling, and burning as well as peripheral neuropathy manifestations like numb feeling in legs and arms
  • Psychological and emotional issues like anxiety, distress, memory loss, mental confusion, and difficulties with decision making and judgement
  • Digestive symptoms like nausea, vomiting, stomach ache, body weight reduction, and loose stools
  • Pallescence
  • Respiratory difficulty
  • Headache and lightheadedness

It should be noted that paleness, lightheadedness, headache, and difficulty breathing also indicate the availability of anemia, namely megaloblastic anemia. This kind of anemia belongs to the major symptoms of folate deficiency which in fact is a cause this anemia. The healthcare provider will recommend performing both folate and vitamin B12 deficiency tests in case of suspecting anemia.
There is also a range of symptoms which occur much rarer but still show the existence of folate deficiency:

  • Tachycardia, which is a too fast heart rate
  • Tachypnoea, which is a very rapid breathing
  • Exfoliative dermatitis, which implies skin redness and peeling on a large scale
  • Heart murmur, which is an abnormal sound of blood flowing
  • Difficulty and aching while swallowing
  • Mouth ulcers and tongue soreness
  • Petechiae, which are very small, typically red sports emerging on the skin
  • Angular stomatitis, which is the inflammation in the corners of a mouth

Folate deficiency can also develop in children who are diagnosed with congenital malabsorption disorders. The latter ones happen rarely and are also accompanied with different neurological issues. But adults much more frequently have abnormally low folate levels.

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